Under the umbrella of Mazumdar Shaw Medical Foundation (MSMF) and Narayana Institute of Neurosciences (NIN), MSMC, Narayana Health, The Integrated Research on Neuroscience program has been initiated. One of the main areas of interest is stroke. Stroke is emerging as significant contributor to disability burden in our country. Neurological recovery after middle cerebral artery strokes remains variable and treatment of impairments are challenging with residual deficits being refractory to existing treatments. Standard of care include thrombolysis, mechanical thrombectomy, decompressive craniectomy if indicated, early rehabilitation. To address residual impairments arising from stroke despite best practices, new treatments in focus include stem cell therapy, neuromodulation, brain machine interface, robotic rehabilitation and multi-modal treatments.The program has been initiated with two major studies: 1) Stem Cell -Based Stroke Management Program 2) Neuroclinical pilot trial of Hyperbaric O2 therapy in progressive supranuclear palsy.