Dr. Aditya Chaubey

ANTI-CANCER TECHNOLOGIES PROGRAM

Dr. Aditya Chaubey, Ph.D.

aditya.chaubey@ms-mf.org

Dr. Aditya Chaubey is the Chief Scientific Officer of Mazumdar Shaw Center for Translational Research and heads the  Anti-Cancer Technologies Program lab. He received his Ph.D. in Bioengineering from Clemson University. His doctoral work involved understanding how biomaterial scaffolds can be used to modulate the differentiation of stem cells. His subsequent work at Cincinnati Children’s Hospital Medical Center elucidated the role of hematopoietic stem cells in myeloid differentiation and the role of microRNA in Acute Myeloid Leukemia (AML). His long-term interest in applying engineering principles to biology led him to the Biomedical Engineering Program at University of Cincinnati, where he worked in the area of orthopedic tissue engineering to develop novel methods to modulate microRNA in skeletal biology. He is currently the Chief Scientific Officer of Mazumdar Shaw Center for Translational Research and heads the Anti-Cancer Technologies Program lab. He is a member of the American Society of Haematology (ASH), Orthopaedic Research Society (ORS), Sigma Xi and Tissue Engineering & Regenerative Medicine International Society (TERMIS) and a reviewer for journals like PLoS One, Journal of Cell Transplantation and Journal of Orthopaedics and Traumatology.

Research Interests

  • Development of novel biomarkers and therapeutics for leukemia
  • In vitro 3D modeling of tumor microenvironments
  • Role of stem cells and microRNA in cancer and skeletal biology
  • Role of mesenchymal stem cells (MSC) in regenerative medicine and tissue engineering applications

Publications

  • Arya, A.D., Hallur, P.H., Karkisaval,A.G., Gudipati,A., Rajendiran, S., Dhavale, V., Ramachandran, B., Jayaprakash, A., Gundiah, N., Chaubey, A. (2016) Gelatin Methacrylate Hydrogels are Biomimetic Matrices for Modeling Breast Cancer Invasion and Chemoresistance In Vitro. ACS Applied Materials and Interfaces. DOI: 10.1021/acsami.6b06309
  • Velu CS#, Chaubey A#, Phelan JD, Horman SR, Wunderlich M, Guzman ML, Jegga AG, Zeleznik-Le NJ, Chen J, Mulloy JC, Cancelas JA, Jordan CT, Aronow BJ, Marcucci G, Bhat B, Gebelein B, Grimes HL. Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity. # Equal contribution. The Journal of Clinical Investigation. 124(1):222-236, 2014.
  • Chaubey A*, Grawe B, Meganck JA, Dyment N, Inzana J, Jiang X, Connolley C, Goldstein S, Kenter K, Awad H, Rowe D, Butler DL. Structural and biomechanical responses of osseous healing: a novel murine nonunion model. Journal of Orthopaedics and Traumatalogy, *Corresponding Author, August 30, 2013.
  • Horman SR, Velu CS, Chaubey A, Bourdeau T, Zhu J, Paul WE, Gebelein B, Grimes HL. Gfi1 integrates progenitor versus granulocytic transcriptional programming. Blood. 28;113(22):5466-75, 2009.
  • Popovic R, Riesbeck LE, Velu CS, Chaubey A, Zhang J, Achille NJ, Erfurth FE, Eaton K, Lu J, Grimes HL, Chen J, Rowley JD, Zeleznik-Le NJ. 2009. Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization. Blood. 2;113(14):3314-22, 2009.
  • Chaubey A, Ross KJ, Leadbetter MR. Gomillion CT, Burg KJL. Characterization of the Differentiation and Leptin Secretion Profile of Adult Stem Cells on Patterned Polylactide Films. Journal of Biomaterials Science, Polymer Edition. 20(7):1163-1177, 2009.
  • Chaubey A, Burg KJL. Extracellular Matrix Components as Modulators of Adult Stem Cell Differentiation in an Adipose System. Journal of Bioactive and Compatible Polymers. 23(1):20-37, 2008.
  • Chaubey A., Ross KJ, Leadbetter RM, Burg KJL. Surface patterning: Tool to Modulate Stem Cell Differentiation in an Adipose System. Journal of Biomedical Materials Research. 84(1):70-8, 2008.